Here's my favorite example of taking a simple block - in this case, the Old Maid's Puzzle block and doing something unique with it. Take a look - it's just some half-square triangles, right? Kind of plain, right? Doesn't do much for you, right?
Aaaaahhhh... but wait a minute! I love this - if you take a block, twist it, turn it, and put lots of these blcoks together, sashed and set with fabrics that have different color values, you can change the whole look of the block and make it absolutely unrecognizable! Here's a set of Old Maid's Puzzle blocks, which I made into a quilt. Can you see the block? Would you have ever guessed this quilt was made of Old Maid's Puzzle blocks?